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KMID : 0358319960370121327
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Korean Journal of Urology
1996 Volume.37 No. 12 p.1327 ~ p.1332
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Effect of Intralesional Interlekin-2 on Murine Bladder Tumor
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김현희
이은식/윤상진/조문기/이종욱
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Abstract
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Purpose:
@EN We tried to evaluate the anticancer effect of intralesional interleukin-2 on murine bladder tumor.
@ES Materials and Methods:
@EN In vitro direct anticancer effect of interleukin-2 upon MBT-2 cells was examined using MTT colorimetric assay in various concentration of human recombinant interleukin-2. Also in vivo study was carried out measuring the tumor implantation
rates
and
growth of the implanted tumors on C3H/He mice receiving six consecutive injections various concentrations of interleukin-2.
@ES Results:
@EN No definite direct anticancer effect was found on in vitro study. Also, the tumor implantation rate and growth of the implanted tumors wee similar whether interleukin-2's were injected or not.
@ES Conclusion:
@EN Intralesional injection of interleukin-2 does not seem to be effective upon murine bladder tumor.
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KEYWORD
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